After being taken to Orio-ya, Tenjin-ya's rival inn, Aoi is put in a confinement room. Although she is all by herself in a strange place, she decides to escape in order to find out who the ayakashi she met when she was a child was.

Based on intel from Sonia, Ace and the gang head toward the Waterfall Cavern, where people from the Guild is gathered. At the same time, Ana left Stella with Angene to visit Crocus. She's excited to see the outside world for the first time, but...

The Straw Hats continue their mad dash to the Sunny! As Big Mom rages, her underlings decide to turn her Hunger Pang attacks against the Straw Hats! The Whole Cake Island scrambles to remake the cake to calm down Big Mom!

Makoto struggles to figure out what she wants to do with her life. While doing so, she makes friends with a fellow third-year, who is dealing with a shady character from Shinjuku.

This is a story that happens inside a human body. One day, as a Red Blood Cell is delivering oxygen and carbon dioxide, she is assaulted by Pneumococci and rescued by a White Blood Cell. To protect the body that’s their world, the White Blood Cell (Neutrophil) chases after the one Pneumococcus who’s escaped. But the enemy has hidden himself in the most unlikely place...

While Hiro and Zero Two head to VIRM's home planet to defeat them, the rest of Squad 13 do their best to get life on Earth back on track.