A mysterious portrait of Lupin appears at a major fashion show in Milan. Portraits of Jigen and Goemon show up as well, so the trio heads to Milan, believing it's some sort of challenge. Zenigata and Fujiko are also there, as are portraits of the two of them. When it's determined that the portraits have been painted by Leonardo Da Vinci, Lupin realizes something and rushes to the church where "The Last Supper" is displayed. What will he find there?!

It turns out that Kayo, absent from school, has disappeared after all. Satoru is tormenting himself with the thought that he should have been able to do something more. On top of that, Aya Nakanishi from the nearby elementary school has vanished too!

A Willwear is en route to the metropolitan government building under an EM dome, ostensibly to exact vengeance on the governor. Unit 8 rallies, but is unable to act without permission from the prefecture. However, their operator, Haruka, has a plan…

Cadis Etrama di Raizel wakes up from 820-years long sleep and starts a new life as a high school student. His peaceful days as a student are soon interrupted as his new human friends are assaulted by mysterious attackers with superhuman abilities.

Sasuke has left with Orochimaru, but Naruto is not about to give up. Determined to bring Sasuke back, he returns to the village with Shikamaru and the others. Meanwhile, Yahiko appears in the village, calling himself “Pain" and seeking revenge for the Hidden Leaf’s betrayal.

The ventriloquist Tengan puts on a show about a ventriloquist who becomes possessed by hiis doll and murders his wife. Tengan falls victim to a genuine split personality disorder, and the personality of his doll appears and orders him to kill his wife Kazuko. Tengan asks Kogoro to watch him so he doesn't kill his wife Kazuko, who had an affair with his apprentice Togawa, but Kogoro turns him down, saying it's not his field of expertise. The next morning, Kazuko is found murdered. Tengan confesses that he may have killed his wife while he was unaware, but...

All of the weak monsters have gone into hiding since a leader of the devil king's army has settled in near town. Kazuma, who had been focusing on improving his skills, is stuck at a standstill. With nothing else to do, Kazuma tags along with Megumin's training, which consists of unleashing explosion magic into an abandoned castle.

Giganto is furious when he learns that Saga and the others killed three Specters to impersonate them against Shaka.

The Spectras arrive at the house of Leo, meeting Aioria.

Mū reachs the remains of the house of Cancer, but is immobilized by a large group led by Spectrum Giganto of Cyclops and Papillon Myu.

Dohko and Shion begin to fight, but the Knight of Libra is overpowered.