At last, Simon and Nia are reunited, and by combining the power of its members, Team Dai-Gurren creates the galaxy-sized Tengen Toppa Gurren-Lagann, and engage the Anti-Spiral threat in a decisive battle to determine the fate of the universe.

After finally transforming their flagship into the Super Galactic Gurren-Lagann, Simon and his friends successfully fight back against the enemy. When their enemy starts to use their own memories and desires against them, Kamina reappears to help.

Team Dai-Gurren struggles to escape from the ocean of despair created by the Anti-Spirals without success, until history repeats itself, as another irreplaceable member of the Team sacrifices himself to save the others.

Haruto proposes to Saki, since he feels guilty about what happened between them. The school is under Dorssian attack. Haruto asks L-elf to drive the Dorrsians out. Shoko attempts to rescue Akira who refuses to go outside. Cain confronts L-elf.

The old world is gone, and Yamato stands poised to remake the world as he sees fit. Hibiki is determined to thwart him, but it will take all his resources as Yamato reveals the true extent of the demon-summoning app's powers. Using its function of demonic fusion, Yamato brings forth Satan himself. In the end, only one will stand before Polaris, who will grant not simply an audience -- to the victor will go the chance to wish for anything they desire.

Tomoe is unhappy with herself and tries to remain aloof, but Kazuya won’t stand for that. He wants to make Tomoe realize that she isn’t plain and help her make friends. But what if there is a reason why she tries to remain invisible...?

A reanimated Granny Chiyo attacks Kankuro and Mifune’s team. Kankuro fights back by using the human puppet of Sasori. The sight of Sasori causes Granny Chiyo to recall the painful memories that led her grandson to create his human puppets.